Aveline's paper shows protective functions of the quiescent HSC population via HGF (enriched in qHSC) and tumor-promoting functions of activated HSC via type I collagen. The balance from quiesent HSC (cytokine and growth factor expressing = cyHSC) to activated myofibroblastic HSC (myHSC) is shifted progressively with disease progression and an impalance is associated with higher risk for HCC in patients. Our paper is one of the first to show a protective function for HSC and my provide novel approaches for HCC prevention (with did not see a role for HSC in HCC progression).
Free access to the pdf:
This UO1 (MPI with Michael Karin and Andrew Lowy, both UCSD; collaborations with Nick Arpaia at Columbia) studies pancreatic cancer stroma, with a focus on how collagen degradation and sensing by specific receptors affects tumor cells and immune responses in PDAC and PDAC liver metastasis.
This paper describes P2Y14 and its ligand as a novel DAMP-DAMP receptor system that directly links hepatocyte death to hepatic stellate cell activation.
Oscar recently graduated from College College in New York City. He will start as lab technician in the Schwabe lab. Oscar's long-term goals are to attend medical school or obtain a PhD in the biomedical field.
Amal recently defended her PhD in Pharmacology at the University of Arkansas and is starting in our lab to study protective functions of hepatic stellate cells in the liver.
NCI grant "Tumor-promoting and tumor-suppressive roles of hepatic stellate cell subpopulations in NASH-HCC." will investigate yet unknown roles of hepatic stellate cells in NASH-induced hepatocellular carcinoma. Thanks to all lab members, and Aveline in particular, for contributing the data and science underlying this grant!
Sonakshi's paper on HSC and liver metastasis made it on the JCI cover
Qiuyan Sun will join our lab for her PhD - welcome!
Ajay's co-first author on "A molecular single-cell lung atlas of lethal COVID-19" published in Nature
The NIDDK grant "Protective and fibrosis-independent functions of hepatic stellate cells" will investigate the poorly understood protective functions of HSC .
Silvia receives an ERC grant to start her own group in Barcelona - wonderful news!
Aveline does it again!
Super news - great job Aveline!