Schwabe lab

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    • Home
    • Members
    • Our Research
    • Lab News
    • Contact us
    • Interested in joining us?
    • Download of our papers
    • Schwabe lab papers
    • The CU-DLDRC Center
    • The Cancer Center (HICCC)
  • Home
  • Members
  • Our Research
  • Lab News
  • Contact us
  • Interested in joining us?
  • Download of our papers
  • Schwabe lab papers
  • The CU-DLDRC Center
  • The Cancer Center (HICCC)

Lab News 2022

August 30, 2022: Aveline's paper on HSC and HCC accepted in Nature - a long journey ended. Congrats!

Aveline's paper shows protective functions of the quiescent HSC population via HGF (enriched in qHSC) and tumor-promoting functions of activated HSC via type I collagen. The balance from quiesent HSC (cytokine and growth factor expressing = cyHSC) to activated myofibroblastic HSC (myHSC) is shifted progressively with disease progression and an impalance is associated with higher risk for HCC in patients. Our paper is one of the first to show a protective function for HSC and my provide novel approaches for HCC prevention (with did not see a role for HSC in HCC progression).


Free access to the pdf:

https://rdcu.be/cWXBd


Pubmed link:

https://pubmed.ncbi.nlm.nih.gov/36198802/

July 19, 2022: Our U01 on pancreatic cancer and liver metastasis will be funded by NCI!!

This  UO1 (MPI with Michael Karin and Andrew Lowy, both UCSD; collaborations with Nick Arpaia at Columbia) studies pancreatic cancer stroma, with a focus on how collagen degradation and sensing by specific receptors affects tumor cells and immune responses in PDAC and PDAC liver metastasis. 

April 6, 2022: Ingmar's/Aveline's/Silvia's paper published in Science Translational Medicine

This paper describes P2Y14 and its ligand as a novel DAMP-DAMP receptor system that directly links hepatocyte death to hepatic stellate cell activation.

https://pubmed.ncbi.nlm.nih.gov/35385339/

Jan 18, 2022: Welcome to our new lab member, Oscar Rodriguez

Oscar recently graduated from College College in New York City. He will start as lab technician in the Schwabe lab. Oscar's long-term goals are to attend medical school or obtain a PhD in the biomedical field. 

Lab News 2020-21

November 18, 2021: Robert designated as "Highly Cited Researcher"

https://recognition.webofscience.com/awards/highly-cited/2021/

November 16, 2021: Welcome to our new lab member, Amal Shoeib!

Amal recently defended her PhD in Pharmacology at the University of Arkansas and is starting in our lab to study protective functions of hepatic stellate cells in the liver.

July 20, 2021: Schwabe lab receives NIH grant

NCI grant "Tumor-promoting and tumor-suppressive roles of hepatic stellate cell subpopulations in NASH-HCC." will investigate yet unknown roles of hepatic stellate cells in NASH-induced hepatocellular carcinoma. Thanks to all lab members, and Aveline in particular, for contributing the data and science underlying this grant!

June 14, 2021: Silvia's paper published in Cancer Cell

Congrats Silvia!


https://pubmed.ncbi.nlm.nih.gov/33930309/

June 1, 2021: Sonakshi's paper gets the JCI cover

Sonakshi's paper on HSC and liver metastasis made it on the JCI cover


https://pubmed.ncbi.nlm.nih.gov/33905375/

May 30, 2021: Welcome Qiuyan

Qiuyan Sun will join our lab for her PhD  - welcome!

April 29 2021: Ajay co-first author on Nature paper

Ajay's co-first author on "A molecular single-cell lung atlas of lethal COVID-19" published in Nature


https://pubmed.ncbi.nlm.nih.gov/33915568/

April 1, 2021: Schwabe lab receives NIH grant

The NIDDK grant "Protective and fibrosis-independent functions of hepatic stellate cells" will investigate the poorly understood protective functions of HSC .

March 5, 2021: Yoshi receives a two year Russ Berrie Foundation grant

Congrats Yoshi!

Feb 9, 2021: Silvia receives an ERC grant

Silvia receives an ERC grant to start her own group in Barcelona - wonderful news! 

June 23, 2020: Aveline selected as sole recipient of the ILCA fellowship on the planet

Aveline does it again!

May 18, 2020: Aveline receives the 2020 Mandl Connective Tissue Research Fellowship

Super news - great job Aveline!


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